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Pharmacologic class: Autonomic nervous system drug
Therapeutic class: Skeletal muscle relaxant (centrally acting)
Pregnancy risk category B
乐动体育开户Unclear. Thought to act primarily at brain stem (and to a lesser extent at spinal cord level) to relieve skeletal muscle spasms of local origin without altering muscle function.
Capsules (extended-release): 15 mg, 30 mg
Tablets乐动体育开户: 5 mg, 7.5 mg, 10 mg
Indications and dosages
➣乐动体育开户 Adjunct to rest and physical therapy to relieve muscle spasm associated with acute, painful musculoskeletal conditions
Adults:乐动体育开户 5 mg P.O. t.i.d. (immediate-release tablet). May increase to 10 mg P.O. t.i.d. (immediate-release tablet) as needed. Or, 15 mg (extended-release capsule) P.O. daily; some patients may need up to 30 mg/day, given as one 30-mg (extended-release capsule) P.O. daily or two 15-mg (extended-release capsules) P.O. daily.
乐动体育开户• Hypersensitivity to drug
乐动体育开户• Acute recovery phase after myocardial infarction (MI)
• Heart failure
乐动体育开户• MAO inhibitor use within past 14 days
乐动体育开户Use cautiously in:
• cardiovascular disease, closed-angle glaucoma, hepatic impairment, increased intraocular pressure, urinary retention
• elderly patients
• pregnant or breastfeeding patients
乐动体育开户• children younger than age 15.
☞ Don't give within 14 days of MAO inhibitor. Drug interaction may cause hypertensive crisis and severe seizures.
• Give extended-release capsule at approximately the same time each day.
• Know that drug shouldn't be used for more than 3 weeks.
乐动体育开户• Be aware that drug may not be first-line agent for elderly patients because of its anticholinergic effects.
CNS: dizziness, drowsiness, syncope, confusion, fatigue, headache, nervousness, decreased mental acuity, irritability, weakness, insomnia, depression, disorientation, delusions, peripheral neuropathy, abnormal gait, Bell's palsy, EEG changes, extrapyramidal symptoms, cerebrovascular accident
CV: vasodilation, tachycardia, chest pain, hypotension, MI, heart block
EENT:乐动体育开户 blurred vision
GI: nausea, constipation, dyspepsia, swollen parotid glands, mouth inflammation, discolored tongue, dry mouth, paralytic ileus
GU: galactorrhea, urinary retention, urinary frequency, gynecomastia, testicular swelling, libido changes, erectile dysfunction
Hematologic: purpura, eosinophilia, bone marrow depression, leukopenia, thrombocytopenia
Metabolic: hyperglycemia, hypoglycemia, syndrome of inappropriate diuretic hormone secretion
Musculoskeletal:乐动体育开户 muscle ache
Skin:乐动体育开户 photosensitization, alopecia, angioedema
Other: unpleasant taste, weight gain or loss, edema
Drug-drug. Anticholinergics, anti-cholinergic-like drugs (including anti-depressants, antihistamines, disopyramide, haloperidol, phenothiazines): additive anticholinergic effects
Antihistamines, CNS depressants, opioids, sedative-hypnotics: additive CNS depression
Guanadrel, guanethidine: reduction in or blockage of these drugs' actions
MAO inhibitors: hyperpyretic crisis, seizures, death
Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression
Drug-behaviors. Alcohol use乐动体育开户: increased CNS depression
• Assess for adverse CNS effects, such as drowsiness, dizziness, and decreased mental acuity.
• Monitor patient for evidence of drug interactions, especially when giving drug with CNS depressants.
• Tell patient to take extended-release capsule at approximately the same time each day.
乐动体育开户• Tell patient that drug may cause dry mouth.
乐动体育开户• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, alertness, and vision.
• Advise patient not to use alcohol, sedatives, pain medications, over-the-counter preparations, or herbs without consulting prescriber.
乐动体育开户• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.
Patient discussion about Flexeril
Q. what are the side effects from taking soma and flexerill together? the person who takes it is almost comatos for a couple of hours. What is a substition?