Fortovase


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Related to Fortovase: Invirase

For·to·vase

(fôr′tō-vās′)
A trademark for the drug saquinavir.
References in periodicals archive ?
COLUMN A COLUMN B Crixivan Combivir Kaletra Retrovir plus Epivir Norvir plus Fortovase Retrovir plus Videx Norvir plus Kaletra Trizivir Sustiva Zerit plus Epivir Viracept Zerit plus Videx
Fortovase. Roche Pharmaceuticals introduced Fortovase[R], which is a new formulation of saquinavir.
Prior genotypic tests show resistance to indinavir (Crixivan), ritonavir (Norvir) and saquinavir (Fortovase) and resistance to all nucleosides except stavudine (Zerit).
For boosting drug levels in the blood, the addition of Norvir to amprenavir (Agenerase), indinavir (Crixivan), or saquinavir (Fortovase) enables these protease inhibitors to be taken with fewer pills.
Despite the quick rebound in these patients, no phenotypic loss of susceptibility was detected to indinavir, nelfinavir (Viracept), ritonavir (Norvir) or saquinavir (Fortovase).
The regimens that have been best documented to work in this context are built on a backbone of ritonavir (Norvir) and saquinavir (Fortovase) along with nucleoside reverse transcriptase inhibitors (NRTIs).
The researchers found that ritonavir co-administered with saquinavir (Fortovase), amprenavir (Agenerase), or indinavir (Crixivan) increased drug trough levels of these drugs by 2, 7, and 24-68 fold, respectively.
saquinavir (Fortovase) plus 2 nucleoside reverse transcriptase inhibitors (NRTIs),
Abbreviations RTV Ritonavir NVP Nevirapine IDV Indinavir DLV Delavirdine NFV Nelfinavir EFV Efavirenz APV Amprenavir ADV Adefovir LPV Lopinavir TNV Tenofovir SQV-H Saquinavir hard gel caps (Invirase) SQV-S Saquinavir soft gel caps (Fortovase)
(*) Saquinavir-SGC, soft-gel capsule (Fortovase): Saquinavir-HGC, hard-gel capsule (Invirase).
Delavirdine increases the blood levels of saquinavir (Fortovase), ritonavir (Norvir), indinavir (Crixivan) and nelfinavir (Viracept).
Efavirenz should not be combined with saquinavir (Fortovase, Invirase) since such co-administration significantly decreases the levels of saquinavir.