ciprofloxacin


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Related to ciprofloxacin: metronidazole

ciprofloxacin

 [sip″ro-flok´sah-sin]
a quinolone antibacterial agent effective against many gram-positive and gram-negative bacteria, including some strains resistant to other agents such as penicillins.

ciprofloxacin

(sĭp′rō-flŏk′sə-sĭn)
n.
A semisynthetic analog of fluoroquinolone that is administered orally and has a broad spectrum of antibiotic activity.

ciprofloxacin

Cipro® Antibiotics A broad-spectrum–GNRs, staphylococci, fluoroquinolone with limited activity against streptococci, anaerobes Indications Acute sinusitis, acute exacerbation of chronic bronchitis, UTI, acute cystitis in ♀, bacterial prostatitis, intra-abdominal infection, skin, bone and joint infection, infectious diarrhea, typhoid fever, gonorrhea Adverse effects GI pain, N&V, diarrhea, seizures, rash, photosensitivity. See Fluoroquinolone.

ciprofloxacin

A fluoroquinolone antibiotic used to treat urinary infections and, as eye drops, for the treatment of corneal ulcers. The drug acts by binding to the enzyme gyrase. Mutations lead to an alteration in the structure of this enzyme leading to antibiotic resistance. Current research suggests the possibility of preventing this process. The drug is on the WHO official list. Brand names are Ciproxin and Ciloxan.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.
References in periodicals archive ?
The British Association of Sexual Health and HIV (BASHH) have recognised the importance of antibiotic stewardship in their recently updated gonorrhea management guidelines, preferring the use of ciprofloxacin over ceftriaxone if antibiotic susceptibility results are available prior to treatment.
All 25 patients with wild-type infections who received ciprofloxacin and returned 7-90 days later tested negative for N.gonorrhoeae.
Quantitative RT-PCR was performed on RNA samples taken at given time points of ciprofloxacin exposure to investigate expression level differences of oqxAB efflux pump.
The percentage of resistance against ciprofloxacin and clindamycin was found to be higher in CA (i.e.
For example, that analysis did not take into consideration the theoretical decrease in ceftriaxone-resistant infections expected with use of ciprofloxacin as an alternative regimen, nor did it take into account other potential benefits of oral therapy over injection therapy.
Stock solutions of ciprofloxacin, ofloxacin, and moxifloxacin containing 200 [micro]g/mL of the drugs were prepared in methanol acidified with 1% acetic acid.
The time to last unformed stool was 43 hours in the rifamycin group and 37 hours in the ciprofloxacin group, which were not significantly different.
Of these isolates, 60 (86.95%) were sensitive to ciprofloxacin (MIC<0.25 mg/mL), 63 (91.30%) were nalidixic acid resistant.
Antibiotic resistance of isolates was as follows: 416 (61%) to ampicillin, 10 (1%) to cefixime, 29 (4%) to ciprofloxacin, and 481 (70%) to TMP/SMX (Table 1).
An older study (Taylor & Bingham, 1997) evaluating antibiotic prophylaxis practices in the United Kingdom reported finding 48 different regimens using 13 different antibiotics, including metronidazole (55%), ciprofloxacin (48%), gentamicin (48%), and trimethoprim (14%).
Results: Topical ciprofloxacin is more effective in earlier control of congestion and discharge of ear in CSOM; (p value = 0.001 and less than 0.005 respectively) as compared to Neomycin.
Stable freeze dried kits of ciprofloxacin is developed through simple stirring at room temperature and labeled with 99mTc after incubation at 35C.Kits produced through this method showed high stability both at room temperature and in serum at 37C.